iMatrix 221
Maintenance and purification of cardiomyocytes and skeletal muscles
Product Basics
iMatrix-221 is highly purified human Laminin 221-E8 fragments recombinantly expressed by CHO-S cell. Laminin-221 E8 fragment protein is known to bind to Intergin α7X2β1 of the cell surface, making an ideal matrix for the differentiation and maintenance of cardiomyocytes and skeletal muscles.
Key Features
- Suitable for the differentiation and maintenance of cardiomyocytes and skeletal muscles
- Exhibits higher binding affinity to α7Xβ1 than Laminin 211
- Clinical grade (iMatrix-221MG) available (contact us for more information)
Technical Information
Differentiated cardiomyocytes pulsating on iMatrix-221
Specification
- Format: Liquid Solution (175 ug/vial @0.5 mg/mL), Solvent: PBS (-)
- Storage temperature: 2-15 °C
- Manufactured by: Nippi, Inc. 1-1-1 Senju-Midoricho, Adachi-ku, Tokyo, Japan
Pricing
iMatrix-221
- Expressed by CHO-S Cell
- Liquid Solution (175 ug/vial @0.5 mg/mL), Solvent: PBS (-)
- Recommended concentration: 0.5µg/cm²
- SKU: N-892063
- Price: $80.00
- Incl. US (Continental) shipping fee
- * Only one purchase per lab *
350ug size (175ug x 2 tubes)
- SKU: N-892061
- Price: $430.00
1050ug size (175ug x 6 tubes)
- SKU: N-892062
- Price: $1,160.00
References & Literature
1. Nishiuchi, R., Takagi, J., Hayashi, M., Ido, H., Yagi, Y., Sanzen N., Tsuji T., Yamada M., & Sekiguchi K. (2006). Ligand-binding specificities of laminin-binding integrins: A comprehensive survey of laminin–integrin interactions using recombinant α3β1, α6β1, α7β1 and α6β4 integrins. Matrix Biology, 25(3), 189-197. https://doi.org/10.1016/j.matbio.2005.12.001
2. Taniguchi, Y., Ido, H., Sanzen, N., Sato-Nishiuchi, R., Futaki, S., & Sekiguchi, K. (2009). The C-terminal Region of Laminin β Chains Modulates the Integrin Binding Affinities of Laminins. The Journal of Biological Chemistry, 284(12), 7820-31. https://doi.org/10.1074/jbc.M809332200
3. Israeli-Rosenberg, S., Manso, A. M., Okada, H., & Ross, R. (2014). Integrins and Integrin-Associated Proteins in the Cardiac Myocyte. Circular Research, 114(3), 572-586. https://doi.org/10.1161/CIRCRESAHA.114.301275
4. Method for producing cardiomyocyte population from pluripotent stem cells. Patent Publication No. WO2016043168 A1. 2017-6-22
Other Documents
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES