PeptiGrowth PG-001
HGF Alternative Peptide
Product Basics
Hepatocyte growth factor (HGF) can be used for inducing hepatocyte differentiation from stem cells and proliferation of hepatocyte and myosatellite cells.
PG-001 replicates the mechanism of action of HGF, inducing dimerization and signaling processes of human c-Met upon binding. It exhibits comparable activity at 1/16 of the concentration of recombinant HGF due to a difference in molecular weight and does not remain in the final products.
Key Features
- Alternative to Hepatocyte Growth Factor (HGF)
- Comparable activity at 1/16 of the concentration of rHGF*
- Demonstrating specific agonist activity for human c-Met.
- Stable. >70% remained after 14 days in serum free media at 37˚C
- Does not remain in the final products
- Fully synthetic and animal-free
GMP grade can be manufactured upon request.
*Please note that this figure is an example and concentration optimization is needed.
Technical Information
(1) PG-001 exhibits comparable activity at 1/16 of the concentration of recombinant HGF.
PeptiGrowth Inc. conducted a functional comparison test between their HGF Alternative Peptide (PG-001) and commercially available recombinant HGF. From the results, PG-001 demonstrated properties that promote the phosphorylation of the c-Met receptor and the proliferation of HUVEC at the same level per molecule compared to recombinant HGF. Considering that the molecular weight of PG-001 is approximately 4.7 kDa, which is about 16 times smaller than that of recombinant HGF, on a mass concentration basis (ng/mL), PG-001 exhibits comparable activity at 1/16th of the concentration of recombinant HGF.
(2) Proliferation and cloning tests of liver cells derived from induced pluripotent stem cells (iPS cells) using recombinant HGF and PG-001.
Professor Hideki Taniguchi at the Institute of Medical Science, University of Tokyo conducted proliferation and cloning tests of liver cells derived from induced pluripotent stem cells (iPS cells) using recombinant HGF or PG-001. As a result, it was confirmed that PG-001 has activity equivalent to HGF at the same level.
Specification
- Storage temperature: -20°C (Ship at 4°C)
- Shelf life: 2 years (To be extended)
- Manufactured by: PeptiGrowth Inc.
Pricing
5ug
- SKU: PG-001-5ug
- Size: 5ug (eq. ~80ug of rHGF)
- Price: $480.00
50ug
- SKU: PG-001-50ug
- Size: 50ug (eq. ~800ug of rHGF)
- Price: $2,400.00
500ug
- SKU: PG-001-500ug
- Size: 500ug (eq. ~8mg of rHGF)
- Price: $15,800.00
References
- Meneghello, G., Storm, M. P., Chaudhuri, J. B., De Bank, P. A. & Ellis, M. J. An investigation into the stability of commercial versus MG63-derived hepatocyte growth factor under flow cultivation conditions. Biotechnology Letters 37, 725–731 (2015) doi: 10.1007/s10529-014-1701-4.
- A growing market for synthetically produced peptides. Nature (2022). https://www.nature.com/articles/d42473-022-00352-2
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES