PeptiGrowth PG-007
VEGF Alternative Peptide (VEGFR2 agonist)
Product Basics
Vascular endothelial growth factor (VEGF) has the ability to promote the proliferation of endothelial cells, and it is also a key differentiation factor for endothelial cells as well as hematopoietic stem cells.
PG-007 serves as an alternative to VEGF and has been confirmed to possess phosphorylation capability on VEGFR2, demonstrating confirmed agonist activity towards VEGFR2. It also shows proliferative activity on iPSC-derived endothelial cells and supports the differentiation of iPSCs into endothelial cells. It exhibits comparable activity at 1/8 of the concentration of recombinant VGEF due to a difference in molecular weight.
Key Features
- Alternative to Vascular Endothelial Growth Factor (VEGF)
- Confirmed agonist activity towards VEGFR2
- Proliferative activity on iPSC-derived endothelial cells
- Comparable activity at 1/8 of the concentration of rVGEF*
- Stable. >80% remained after 14 days in serum free media at 37˚C
- Fully synthetic and animal-free
GMP grade can be manufactured upon request.
*Please note that this figure is an example and concentration optimization is needed.
Technical Information
(1) Confirmed agonist activity towards VEGFR2 and proliferative activity on iPSC-derived endothelial cells.
(2) Synthetic Peptide Growth Factors for iPSC-based Hematopoietic Stem Progenitor Cells (HSPCs) and NKT Cells
Differentiation efficiency of human iPSCs into endothelial cells (ECs) was evaluated when using recombinant VEGF or PG-007 (prototype)
Differentiation of iPSCs into NKT cell through hematopoietic stem and progenitor cells (HSPCs), using PeptiGrowth peptides (PG-007, 008 and 010) or using VEGF, CHIR99021 (Wnt3a agonist), and TPO.
Using PeptiGrowth peptides (PG-007, PG-008, and PG-010) reduced the culture period by one day and resulted in more than twofold increase in HSPC yield.
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Specification
- Storage temperature: -20°C (Ship at 4°C)
- Shelf life: 2 years (To be extended)
- Manufactured by: PeptiGrowth Inc.
Pricing
5ug
- SKU: PG-007-5ug
- Size: 5ug (eq. ~40ug of rVEGF)
- Price: $380.00
50ug
- SKU: PG-007-50ug
- Size: 50ug (eq. ~400ug of rVEGF)
- Price: $1,750.00
500ug
- SKU: PG-007-500ug
- Size: 500ug (eq. ~4mg of rVEGF)
- Price: $12,000.00
References
- Goolcharran, C., Jones, A. J. S. & Borchardt, R. T. Comparison of the rates of deamidation, diketopiperazine formation, and oxidation in recombinant human vascular endothelial growth factor and model peptides. AAPS PharmSci 2, 5 (2000) doi: 10.1208/ps020105.
- Shibuya, M. Vascular Endothelial Growth Factor (VEGF)-Receptor2: Its Biological Functions, Major Signaling Pathway, and Specific Ligand VEGF-E. Endothelium 13, 63–69 (2006) doi: 10.1080/10623320600697955.
- Shibuya, M. VEGFR and Type-V RTK Activation and Signaling. Cold Spring Harb Perspect Biol. 5, a009092 (2013) doi: 10.1101/cshperspect.a009092.
- Ribatti, D. The discovery of the fundamental role of VEGF in the development of the vascular system. Mechanisms of Development 160, 103579 (2019) doi: 10.1016/j.mod.2019.103579.
- A growing market for synthetically produced peptides. Nature (2022).
https://www.nature.com/articles/d42473-022-00352-2
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES