iMatrix-411 is a recombinant Laminin-411 E8 fragment protein used as a cell culture matrix. Laminin-411 is a predominant isoform found in the basal membrane of the endothelial cells in capillary vessels, and it mainly binds to the cell surface transmembrane receptors integrin α6β1 and α71β1.¹ The E8 fragment maintains full binding activity toward integrin, yet lacks binding activities to other components. The process of switching defined matrices is a critical tool for steering cells towards their intended fate.² Studies have demonstrated that switching the extracellular matrix (ECM) from laminin-511 E8 fragment (iMatrix-511) to laminin-411 E8 during differentiation efficiently induces endothelial progenitor cells from iPS cells. 

¹ Nishiuchi, R. et al. Matrix Biol. 25, 189-197-,2006
² Ohta R et al., Scientific Reports, 6(35680), 1-12, 2016